Mini片段亲电杂环库
Since screening electrophilic fragments has become a promising alternative to discovering ａnd verifying new targets ａnd generating viable chemical starting points, we designed a Mini Electrophilic Heterocyclic Fragment Library. These compounds are basically covalent MiniFrags, containing five- ａnd six-membered nitrogen-containing heterocycles with electron-withdrawing properties that can activate small electrophilic substituents (halogen, ethynyl, vinyl, ａnd nitrile groups). The library contains not only small electrophilic heterocycles, but also N-quaternized analogs with increased reactivity. 371 compounds in total in the Highly Solubility Covalent Heterocyclic Fragment Library
 

Product Description

The theoretical basis of FBDD is to ｓelect favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect ａnd manage. In addition, fragments have smaller molecular weights, relatively higher solubility, ａnd easier structural optimization. The potential of over-the-counter medicine is higher. Targeted covalent inhibitors ａnd chemical probes have become part of drug discovery methods. Given the advantages of fragment-based drug discovery, screening electrophilic fragments has become a promising alternative to discover ａnd verify new targets ａnd generate viable chemical starting points, even for targets that are almost difficult to handle. In response to this situation, we designed a small library of heterocyclic electrophilic compounds.

General technology for covalent fragment screening ：

化合物库定制

我们的化合物库可以灵活定制！ 了解更多
 

品牌介绍：
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化域科学家的研究提供业的产品和服务。TargetMol品牌的客户群分布于40多个国家和地区，已发展成为全球大的化合物库和小分子化合物研究供应商。

☆ TargetMol®品牌业提供各域信号通路小分子抑制剂、拮抗剂、天然产物、药物筛选化合物。
☆ 产品适应在癌症、免疫学、心血管系统、呼吸、神经科学等多项科学域的研发使用，超过1180万种小分子化合物。
☆ 提供20000多个小分子抑制剂、天然产物和200多个化合物库。
☆ 配备完善的化学合成和生物实验室，可分别提供高品质小分子抑制剂和药物筛选技术服务。
☆ 每批产品都有严格的NMR和HPLC技术检测，以保证产品高纯度高质量。

  
  

 

原创作者：上海陶术生物科技有限公司