高溶解性3D结构多样性片段库

The highly soluble structural diversity fragment compound library is constructed in an efficient ａnd modular manner, so it is very suitable for solving the current situation that a large amount of synthetic investment is required to achieve multi-directional fragment growth. The structurally diverse fragments are designed to contain suitable synthetic reactive groups for future fragment growth. The library of highly soluble 3D structural diversity fragments contains 1083 compounds.
 

Product Description

Traditional drug research ａnd development are mainly based on natural active products or screening new drugs from existing compound data, but this method is highly random, blind, ａnd inefficient. Medicinal chemists subsequently developed high-throughput screening (HTS) methods for drug discovery. Many pharmaceutical companies have also established compound libraries containing millions of small molecules ａnd discovered many drug candidates. However, in drug screening with complex targets, HTS has been repeatedly frustrated. It is difficult to screen high-potential compounds, or the screened compounds have high false positives ａnd poor drug-like properties. In this context, Fragment-based drug design (FBDD) came into being. Organic synthesis can transform miniature hits into effective lead compounds. The deficiencies in the current screening of compound libraries usually result in the need for a large amount of synthetic investment to achieve multi-directional fragment growth, which limits the efficiency of the mini-fragment hit modification process. To meet this challenge, we designed a library of highly soluble 3D structural diversity fragments.

The utility of X-ray-based fragment screening ａnd the ability to achieve rapid analog synthesis:

 

化合物库定制

我们的化合物库可以灵活定制！ 了解更多
 

品牌介绍：
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化域科学家的研究提供业的产品和服务。TargetMol品牌的客户群分布于40多个国家和地区，已发展成为全球大的化合物库和小分子化合物研究供应商。

☆ TargetMol®品牌业提供各域信号通路小分子抑制剂、拮抗剂、天然产物、药物筛选化合物。
☆ 产品适应在癌症、免疫学、心血管系统、呼吸、神经科学等多项科学域的研发使用，超过1180万种小分子化合物。
☆ 提供20000多个小分子抑制剂、天然产物和200多个化合物库。
☆ 配备完善的化学合成和生物实验室，可分别提供高品质小分子抑制剂和药物筛选技术服务。
☆ 每批产品都有严格的NMR和HPLC技术检测，以保证产品高纯度高质量。

  
  

 

原创作者：上海陶术生物科技有限公司