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高溶解性微型片段库
 
 
  • 产品名称:高溶解性微型片段库
  • 产品型号:
  • 产品产地:中国大陆
  • 采购热度:835
  • 简介内容:The compound library of highly soluble micro-fragments consists of 1082 low-molecular-weight fragments.
详细内容/Content

高溶解性微型片段库

高溶解性微型片段库

The compound library of highly soluble micro-fragments consists of 1082 low-molecular-weight fragments. Low-molecular-weight compounds (so-called micro-fragments) are derived from commercially available fragment spaces. The focus is on ensuring the chemical stability of the compound, the absence of reactive compounds, meeting the physical and chemical characteristics of the screening, and not strictly complying with the drug similarity standards, the structural diversity of compounds/covering a wider chemical space, aims to provide hit drug targets for the fields of new drug discovery and drug design.
 

Product Description

Traditional drug research and development are mainly based on natural active products or screening new drugs from existing compound data, but this method is highly random, blind, and inefficient. Medicinal chemists subsequently developed high-throughput screening (HTS) methods for drug discovery. Many pharmaceutical companies have also established compound libraries containing millions of small molecules and discovered many drug candidates. However, in drug screening with complex targets, HTS has been repeatedly frustrated. It is difficult to screen high-potential compounds, or the screened compounds have high false positives and poor drug-like properties. In this context, Fragment-based drug design (FBDD) came into being.

Feature:

  1. The chemical properties are stable, the structure is diverse, and the chemical space is widely distributed;
  2. Each fragment has been tested for solubility: DMSO (200 mM) and PBS (1 mM);
  3. The molecular weight of most fragments is less than 300, and the number of hydrogen bond donors and acceptors is not higher than 3;
  4. Strict quality control, and the purity of the compounds is above 95%;

化合物库定制

我们的化合物库可以灵活定制! 了解更多
 

品牌介绍:
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化域科学家的研究提供业的产品和服务。TargetMol品牌的客户群分布于40多个国家和地区,已发展成为全球大的化合物库和小分子化合物研究供应商。

☆ TargetMol®品牌业提供各域信号通路小分子抑制剂、拮抗剂、天然产物、药物筛选化合物。
☆ 产品适应在癌症、免疫学、心血管系统、呼吸、神经科学等多项科学域的研发使用,超过1180万种小分子化合物。
☆ 提供20000多个小分子抑制剂、天然产物和200多个化合物库。
☆ 配备完善的化学合成和生物实验室,可分别提供高品质小分子抑制剂和药物筛选技术服务。
☆ 每批产品都有严格的NMR和HPLC技术检测,以保证产品高纯度高质量。

  
  

 

原创作者:上海陶术生物科技有限公司

标签:高溶解性   化合微库   药物筛选   分子库   药物   

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