TargetMol®高溶解性多官能团片段库

The design principle of the highly soluble multifunctional fragment library is to allow rapid, cheap follow-up synthesis to provide quick SAR data. Poised fragments contain at least one functional group which can be synthesised using a robust, well-characterised reaction. Reactions include amide couplings, Suzuki-type aryl-aryl couplings ａnd reductive aminations. Highly soluble multifunctional fragment library contains 1159 kinds of fragment molecules.
 

TargetMol®高溶解性多官能团片段库Product Description

Traditional drug research ａnd development are mainly based on natural active products or screening new drugs from existing compound data, but this method is highly random, blind, ａnd inefficient. Medicinal chemists subsequently developed high-throughput screening (HTS) methods for drug discovery. Many pharmaceutical companies have also established compound libraries containing millions of small molecules ａnd discovered many drug candidates. However, in drug screening with complex targets, HTS has been repeatedly frustrated. It is difficult to screen high-potential compounds, or the screened compounds have high false positives ａnd poor drug-like properties. In this context, Fragment-based drug design (FBDD) came into being.

The theoretical basis of FBDD is to ｓelect favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect ａnd manage. In addition, fragments have smaller molecular weights, relatively higher solubility, ａnd easier structural optimization. The potential of over-the-counter medicine is higher. The high solubility multifunctional fragment library is designed by analyzing the spatial stability of all commercially available fragments ａnd selecting a chemically diverse subset. In order to enhance the diversity of the compound library, we carefully selected some additional saturated heterocyclic compounds to supplement the compound library.

化合物库定制

我们的化合物库可以灵活定制！ 了解更多
 

品牌介绍：
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化域科学家的研究提供业的产品和服务。TargetMol品牌的客户群分布于40多个国家和地区，已发展成为全球大的化合物库和小分子化合物研究供应商。

☆ TargetMol®品牌业提供各域信号通路小分子抑制剂、拮抗剂、天然产物、药物筛选化合物。
☆ 产品适应在癌症、免疫学、心血管系统、呼吸、神经科学等多项科学域的研发使用，超过1180万种小分子化合物。
☆ 提供20000多个小分子抑制剂、天然产物和200多个化合物库。
☆ 配备完善的化学合成和生物实验室，可分别提供高品质小分子抑制剂和药物筛选技术服务。
☆ 每批产品都有严格的NMR和HPLC技术检测，以保证产品高纯度高质量。

原创作者：上海陶术生物科技有限公司