简介内容:WEE1-IN-5 (Debio 0123) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. WEE1-IN-5 inhibits phospho-CDC2 which translated into an increase in DNA damage and premature entry into mitosis. WEE1-IN-5 increases the antitumoral activity of Carboplatin in vivo whereas neither agent was active alone [1].
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Debio-0123
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产品名称:Debio-0123 CAS:2243882-74-6 产品介绍:WEE1-IN-5 (Debio 0123) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. WEE1-IN-5 inhibits phospho-CDC2 which translated into an increase in DNA damage and premature entry into mitosis. WEE1-IN-5 increases the antitumoral activity of Carboplatin in vivo whereas neither agent was active alone [1].
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