简介内容：AM679 is a potent and selective FLAP inhibitor with IC50s of nM/ nM/154 nM for FLAP binding/hLA/hWB respectively. IC50 value: nM/ nM/154 nM(FLAP binding/hLA/hWB) [1] AM679 showed an improved CYP inhibition profile (IC50 3A4 = lM, 2C9 = lM, 2D6 >30 lM), no time dependent inhibition against CYP3A4 ( min-1 vs min-1 for troleandomycin control 10 uM) and no CYP3A4 induction. AM679 has an excellent hWB IC50 potency of 154 nM. Target: FLAP in vitro: AM679 showed excell
Customer Service
