CBR-5884；化合物CBR-5884CBR-5884T14884 - 上海陶术生物科技有限公司

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产品名称：CBR-5884；化合物CBR-5884CBR-5884
产品型号：T14884
产品产地：中国大陆
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简介内容：CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time

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原创作者：上海陶术生物科技有限公司

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