简介内容:VU0467485 is a potent and selective muscarinic acetylcholine receptor 4 positive allosteric modulator. VU0467485 potentiates the activity of ACh at M4 (EC50s: nM and nM at the rat and human M4 receptors, respectively). VU0467485 displays selectivity for M4 over human and rat M1/2/3/5.