简介内容：Verlukast is an (R)-enantiomer of MK-571 and a potent and selective LTD4 receptor antagonist. Verlukast showed [3H]leukotriene D4 binding in guinea-pig (IC50 = +/- nM) and human (IC50 = +/- nM) lung homogenates and dimethyl sulfoxide differentiated U937 cell membrane preparations (IC50 = +/- nM) but is essentially inactive versus [3H]leukotriene C4 binding in guinea-pig lung homogenates (IC50: 19 and 33 microM).
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