简介内容:Medetomidine (Domtor) is a potent, highly selective α2-adrenoceptor agonist, demonstrating Ki values of nM for α2-adrenoceptors and 1750 nM for α1-adrenoceptors, indicating significant selectivity for α2 over α1 receptors compared to clonidine and UK 14,304 with 1620-, 220-, and 300-fold respectively. Medetomidine significantly inhibits the twitch response in electrically stimulated mouse vas deferens (pD2 = ), showcasing its efficacy. Exhibiting a wide range of pharmacological effects,