简介内容：BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = nM). In addition, BMS-665053 is efficacious in the Defensive Withdrawal model of anxiety in rats and has low in vivo clearance (Cl = 17 mL/min/kg, t? = h) in rats.
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