简介内容:ONO-0300302 is a slow tight binding LPA1 antagonist (IC50: nM) used to treat Benign Prostatic Hyperplasia. ONO-0300302 inhibits significantly an LPA-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, .) and dog (1 mg/kg, .) over 12 h.