COH29；化合物COH29RNR Inhibitor COH29；RNR Inhibitor COH29T3157

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产品名称：COH29；化合物COH29RNR Inhibitor COH29；RNR Inhibitor COH29
产品型号：T3157
产品产地：中国大陆
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简介内容：COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR inhibitor COH29 binds to the ligand-binding pocket of the RNR M2 subunit (hRRM2) near the C-terminal tail. Inhibition of RNR activity decreases the pool of deoxyribonucleotide triphosphates available for DNA synthesis. The resulting decrease in DNA synthesis causes cell cycle arre

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原创作者：上海陶术生物科技有限公司

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