简介内容：IDE1 can induce definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50: nM in vitro) by activating the TGF-β signaling pathway. IDE1-derived endodermal cells injected into mouse embryos ex vivo have been shown to incorporate into the developing gut tube, contributing to its formation.
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