简介内容：I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of nM. I-SAP binds to human platelets with the maximum binding obtained between pH and pH . In washed human platelets, the Kd for I-SAP is 468 pM at pH and 490 pM at pH .
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