简介内容：16F16 is a protein disulfide isomerase (PDI) inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal
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