简介内容:T-5342126 is a toll-like receptor 4 (TLR4) reduces LPS-induced production of nitric oxide (NO) in RAW cells (IC50= μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = , , and μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-depen