Evofosfamide；艾伏磷酰胺TH-302；艾伏磷酰胺|||TH-302T3615

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产品名称：Evofosfamide；艾伏磷酰胺TH-302；艾伏磷酰胺|||TH-302
产品型号：T3615
产品产地：中国大陆
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简介内容：Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed to hypoxic conditions, such as those found in hypoxic tumors, the 2-nitroimidazole moiety of evofosfamide is reduced. This releases the DNA-alkylating Br-IPM moiety, which introduces intra- and inter-strand DNA crosslinks in nearby cells; the crosslinks inhibit both DNA replication and cell division an

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原创作者：上海陶术生物科技有限公司

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