简介内容:PF-06843195 is a selective PI3Kα inhibitor, demonstrating potent activity with an IC50 of 18 nM in Rat1 fibroblasts and Kis for PI3Kα and PI3Kδ less than nM and nM, respectively, in biochemical kinase assays. It effectively suppresses the PI3K/mTOR signaling pathway and exhibits durable antitumor efficacy[1].