简介内容：SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki= nM). SB-612111 exhibits selectivity for μ-, κ- and δ-receptors with Ki values of nM, nM and 2109 nM, respecticely. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model[1].
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