简介内容：NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = , , , , and μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
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