简介内容:8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.