简介内容：ASIC blocker (IC50 values are , μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are , and uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are and uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
Customer Service
