简介内容:Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities. It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = and μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = μM), in vitro. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of μM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs =