简介内容:GSK143 is a potent orally active and highly selective inhibitor of spleen tyrosine kinase (SYK) with a pIC 50 of . Furthermore, GSK143 effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of . In addition, GSK143 exhibits promising anti-inflammatory properties by reducing inflammation and impeding the recruitment of immune cells in the intestinal muscularis of mice.