简介内容:LeuRS-IN-1 is a highly potent and orally active inhibitor of the leucyl-tRNA synthetase enzyme derived from Mycobacterium tuberculosis ( LeuRS). It exhibits significant inhibitory activity against LeuRS with IC 50 and Kd values of μM and μM, respectively. Additionally, LeuRS-IN-1 effectively inhibits human cytoplasmic LeuRS with an IC 50 value of μM and suppresses protein synthesis in HepG2 cells with an EC 50 value of μM.