简介内容：FTI 277 is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are and 10μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
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