I-CBP112 hydrochloride；化合物I-CBP112 hydrochlorideI-CBP112 hydrochlorideT4247

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产品名称：I-CBP112 hydrochloride；化合物I-CBP112 hydrochlorideI-CBP112 hydrochloride
产品型号：T4247
产品产地：中国大陆
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简介内容：I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.

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原创作者：上海陶术生物科技有限公司

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