简介内容:Poseltinib is an orally active, selective, and irreversible Bruton´s tyrosine kinase (BTK) inhibitor, exhibiting a half-maximal inhibitory concentration (IC 50) of nM. It demonstrates , , and greater selectivity for BTK over BMX, TEC, and TXK, respectively. This compound covalently binds to BTK´s active site at the cysteine 481 residue, effectively inhibiting signaling pathways mediated by the B cell receptor (BCR), Fc receptor (FcR), and Toll-like receptor (TLR).