Ro5-3335；化合物Ro 5-3335CBFβ-Runx1 inhibitor II|||Ro 5-3335；CBFβ-Runx1 inhibitor II|||Ro 5-3335T4687

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产品名称：Ro5-3335；化合物Ro 5-3335CBFβ-Runx1 inhibitor II|||Ro 5-3335；CBFβ-Runx1 inhibitor II|||Ro 5-3335
产品型号：T4687
产品产地：中国大陆
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简介内容：Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.

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原创作者：上海陶术生物科技有限公司

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