简介内容：AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor with IC 50 of μM. AV123 blocks the TNF-α-induced necroptotic with EC 50 of μM, but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases [1].
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