简介内容:ROS 234 is a highly effective H3 antagonist, demonstrating a strong binding affinity (pK B) of for the Guinea-pig ileum H3 receptor and a pKi of for the Rat cerebral cortex H3 receptor. Additionally, it exhibits an ex vivo ED50 of mg/kg (ip) in the Rat cerebral cortex. It should be noted that ROS 234 demonstrates limited central access, as reported in [1] and [2].