简介内容:CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist with an IC50 of μM. CAY10789 is also a GPBAR1 (G-protein-coupled bile acid receptor 1) agonist with an EC50 of 3 μM. CAY10789 significantly decreases the adhesion of U937 cells to HAEC and decreases the expression of TNF-α. CAY10789 exhibits very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used in the study of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-relate