简介内容：PDE4-IN-9 (Compound 5j) is a potent PDE4 inhibitor. In vitro enzyme assay, the IC 50 value of PDE4-IN-9 against PDE4 is μM which is lower than μM of parent rolipram. PDE4-IN-9 also shows good in vivo activity in LPS-induced animal models of asthma/COPD and sepsis [1].
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