简介内容:AAK1-IN-5 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), characterized by its ability to penetrate the central nervous system and its oral bioavailability. It displays high selectivity, with an AAK1 inhibitory potency (IC 50) of nM, a binding affinity (K i) of nM, and an inhibitory potency against cellular AAK1 activity (cell IC 50) of nM. AAK1-IN-5 holds promise for investigating neuropathic pain in scientific research [1].