简介内容：CM398 is an orally active chemical compound that acts as a highly selective ligand for the sigma-2 receptor (K i = nM), demonstrating a significant ratio of selectivity between sigma-1 and sigma-2 receptors (1000-fold). Moreover, CM398 exhibits notable affinity towards dopamine (K i = nM) and serotonin transporters (K i = nM). In addition, CM398 has shown promising efficacy as an anti-inflammatory analgesic in a mouse model of inflammatory pain induced by formalin [1].
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