简介内容:Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of nM against TrkA and nM against TrkA G595R. As an RTK, Trk plays a crucial role as a drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) demonstrates superior selectivity in inhibiting Trk, which has potential implications for toxicity reduction [1].