简介内容：SHP2-IN-8 is a reversible, noncompetitive, selective and efficient allosteric SHP2 inhibitor (IC50=23 nM, Ki=22 nM), which also has effects in cells. SHP2-IN-8 can cause significant thermal displacement（ Δ Tm = ℃）。 SHP2-IN-8 can inhibit the phosphorylation of AKT and induce apoptosis of Hela cells.
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