简介内容:PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: nM). PDE5-IN-3 has a moderate inhibitory effect on EGFR (IC50: μM). PDE5-IN-3 markedly inhibits the Wnt/β-catenin pathway with an IC50 value of ng/mL. PDE5-IN-3 induced the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and PDE5-IN-3 exhibited significant antitumor effects.