简介内容:ZLMT-12 (compound 35) is a tacrine derivative and a potent inhibitor of CDK2 (IC50: μM) and CDK9 (IC50: μM). ZLMT-12 weakly inhibits AChE (IC50: μM) and BuChE (IC50: μM). ZLMT-12 has anti-proliferative activity and low cytotoxicity. ZLMT-12 blocks the cell cycle in S-phase and G2/M-phase and induces apoptosis.