Cbl-b-IN-3；化合物Cbl-b-IN-3Cbl-b-IN-3T63790 - 上海陶术生物科技有限公司

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产品名称：Cbl-b-IN-3；化合物Cbl-b-IN-3Cbl-b-IN-3
产品型号：T63790
产品产地：中国大陆
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简介内容：Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.

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原创作者：上海陶术生物科技有限公司

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