简介内容:ALK-IN-23 is a potent inhibitor of ALK, acting on ALKWT (IC50: nM), ALKL1196M (IC50: nM) and ALKG1202R (IC50: nM). -IN-23 has inhibitory effects on cancer cell migration and colony formation in vitro. In the H2228 xenograft nude mouse model, ALK-IN-23 showed good anti-tumour effects with low toxicity.