简介内容：NXPZ-2 is an orally active Keap1-Nrf2protein-protein interaction (PPI) inhibitor (Ki: 95 nM, EC50: 120 and 170 nM). NXPZ-2 dose-dependently attenuates Aβ[1-42]-induced cognitive disturbances, enhances neuronal number and function, and enhances pathological alterations in the brain of Alzheimer´s disease (AD) has potential for studies of Keap1-Nrf2 PPI inhibitors and AD-related disorders.
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