NSC697923；化合物NSC6979232-[(4-methylphenyl)sulfonyl]-5-nitrofuran；2-[(4-methylphenyl)sulfonyl]-5-nitroT6611

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产品名称：NSC697923；化合物NSC6979232-[(4-methylphenyl)sulfonyl]-5-nitrofuran；2-[(4-methylphenyl)sulfonyl]-5-nitro
产品型号：T6611
产品产地：中国大陆
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简介内容：NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage

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原创作者：上海陶术生物科技有限公司

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