简介内容:Ro 31-8220 is a potent inhibitor of PKC with IC 50 s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β with IC50s of 3, 8, 15, and 38 nM, respectively without effect on MKK3, MKK4, MKK6 and MKK7.