简介内容：HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor, displaying K i values of μM for DAPK3, μM for Pim-3, μM for Pim-1, and >100 μM for Pim-2. This compound effectively inhibits LC20 phosphorylation and smooth muscle contraction, and reduces blood pressure in spontaneously hypertensive mice, making it a valuable tool for hypertension research.
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