简介内容：SF0166 is a potent, selective antagonist of α v β 3, demonstrating IC 50 values of nM for α v β 3, 8 nM for α v β 6, and 13 nM for α v β 8. It effectively inhibits cellular adhesion to vitronectin in human, rat, rabbit, and dog cell lines, with IC 50 values ranging from pM to 76 nM. Additionally, SF0166 significantly reduces neovascularization in the oxygen-induced retinopathy mouse model.
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