简介内容：AZ-Tak1 is a potent and a relatively selective inhibitor of TAK1 kinase activity, with an IC50 of mM. AZ-Tak1 treatment decreased the level of p38 and ERK in mantle cell lymphoma cells, and induced apoptosis in a dose and time dependent manner, with an IC50 of – mM. Using the annexin-V and PI staining and FACS analysis, After 48 hours of incubation, AZ-Tak1 ( mM) induced apoptosis in 28%, 34% and 86% of Mino, SP53, and Jeko cells, respectively, which was increased to 32%, 42%, and
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