简介内容：KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (., 50% inhibition of cell growth) for KRC-108 ranged from to μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumo
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