简介内容：SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = nM, Capan-1 BRCA2 deficient, IC50 = nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = μM). SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treat
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